新型药物制剂中心(Research Center of Novel Drug Delivery Systems)-广东工业大学生物医药学院

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新型药物制剂中心(Research Center of Novel Drug Delivery Systems)

作者: 时间:2019-01-10 点击数:

近几年,随着大量生物工程及基因工程药物的出现,各国药学科学家都充分认识到新型药物制剂的研究是新药研发的关键环节。目前微囊化技术、固体分散体技术、包合技术、纳米技术等诸多新剂型和新技术已为药物制剂的开发以及制剂质量的提高奠定了坚实的基础。新型药物制剂的研发是一个复杂的过程,需要新型药用材料、新型制备设备、新包装技术及新临床评价方法的相互配合。本团队在微丸、微球、微针、缓控释片、乳剂、固体分散体、吸入制剂、介孔硅胶给药系统、立方液晶给药系统、基因传递系统这十大药物制剂研究平台上均有深厚的基础及突出的成果,同时,这些技术平台已成为药物制剂研究的主导方向,在国内同行中具有一定的影响力。目前,新型药物制剂中心拥有国际一流的实验条件及先进设备,其主要包括:流化床、旋转压片机、胶囊填充机、喷雾干燥机、超微粒制备系统、全自动微针制备系统、软胶囊机、热熔挤出机、气流粉碎机、高效智能包衣机、费休氏水分测定仪、高压均质机、冷冻干燥机、自动取样溶出仪、高效液相色谱仪、激光粒度分析仪(微米级和纳米级)、多级药用撞击器(NGIACI)、功率补偿型差示扫描量热仪等。


        With recent emergence of various biological and genetic  therapeutic drugs,worldwide pharmaceutical scientists have realized the  importance of research inthe development of new drug discovery。 Great  advances in the investigation of novelpharmaceutical formulations and  the techniques such as microencapsulation, soliddispersions, inclusion  compounds and nanotechnology that provide diverse possibilitiesfor the  further pharmaceutical development and enhancement of formulation  quality。Although the development process of novel pharmaceutical  formulations can bevery difficult, in which it requires innovative  pharmaceutical excipients, preparationfacilities, packaging techniques,  and methods for clinical evaluation。 Our teamhas already created a solid  foundation and obtained promising outcomes on a varietyof drug delivery  platforms including pellets, microspheres, microneedles,sustained and  controlled release tablets, emulsions, solid dispersions,inhalation  formulations, mesoporous silica- and liquid cubosome based drugdelivery  systems as well as gene delivery systems。 All these top ten platforms  havebecome the mainstream directions in formulation research and our  researchprojects also having a particularly strong academic influence in  nationally。 Currently,the Research Center of Novel Drug Delivery  Systems has world-class experimentalfacilities that include fluidized  bed, rotary tablet press, capsule fillingmachine, spray dryer,  ultra-fine particle processing system (UPPS), automatic microneedlearray  fabrication system (AMFS), soft capsule machine, hot-melt extruder,  airflowcrusher, high efficiency coater, moisture analyzer, high pressure  homogenizer, lyophilizer,auto dissolution tester, high-performance  liquid chromatography (HPLC), micro-and nanoparticle size analyzer,  multi-level medical impactor (NGI and ACI), differentialscanning  calorimeter etc。


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